Protein Details: Transient receptor potential cation channel subfamily M member 4
Protein ID
ICDB_Pro_1488
Protein Name
Transient receptor potential cation channel subfamily M member 4
Gene Name
Trpm4; Ltrpc4
Organism
Rattus norvegicus (Rat)
Length
1208 amino acids
AlphaFoldDB
AF-Q9ESQ5-F1-model_v4.pdb
Function
Sequence
MVGQEKEQSWIPKIFRKKVCTTFIVDLHDDAGGTLCQCGQPRDAHPSVAVEDAFGAAVVTEWNSDEHTTEKPTDAYGDLDFTYSGRKSSNFLRLSDRTDPATVYSLVTRSWGFRAPNLVVSVLGGSEGPVLQTWLQDLLRRGLVRAAQSTGAWIVTGGLHTGIGRHVGVAVRDHQTASTGGSKVVAMGVAPWGVVRNRDMLINPKGSFPARYRWRGDPEDGVEFPLDYNYSAFFLVDDGTYGRMGGENRFRLRFESYVAQQKTGVGGTGIDIPVLLLLIEGDEKMLKRIEDATQAQLPCLLVAGSGGAADCLVETLEDTLAPGSGGLRRGEARDRIRRYFPKGDPEVLQAQVERIMTRKELLTVYSSEDGSEEFETIVLRALVKACGSSEASAYLDELRLAVAWNRVDIAQSELFRGDIQWRSFHLEASLMDALLNDRPEFVRLLISHGLSLGHFLTPVRLAQLYSAVSPNSLIRNLLDQASHASSSKSPPANGAAELRPPNVGQVLRTLLGETCAPRYPARNTRHSLLGQDHRENDSLLMDWANMQQDASFEQAPWSDLLIWALLLNRAQMAIYFWEKGSNSVASALGACLLLRVMARLEWEAEEAARRKDLAAKFESMSVDLFGECYHNSEYRAARLLLRRCPLWGEATCLQLAMQADARAFFAQDGVQSLLTQKWWGEMDSTNPIWALLLTFFCPPLIYTNLILFRKSEEEPTQKDLDFDMDSSMNGAGPLGPAEPSAKVALERRRRRRPGHTLCCGGCSKRWSYFWGAPVTAFLGNVVSYLLFLLLFAHVLLVDFQPTKPGVFELLLYFWAFTLLCEELRQGLGGGWGTLANGGPGPGKAPLRHRLHLYLLDTWNQCDLLALTCFLLGVGCRLTPGLFDLGRTVLCLDFMIFTLRLLHIFTVNKQLGPKIVIVSKMMKDVFFFLFFLCVWLVAYGVATEGILRPQDRSLPSILRRVFYRPYLQIFGQIPQEEMDVALMNPSNCSAERGSWAHPEGPVAGSCVSQYANWLVVLLLIVFLLVANILLLNLLIAMFSYTFNKVHGNSDLYWKAQRYSLIREFHSRPALAPPLIIISHLRLLFKWLRRCHRTNLPASPVFEHFRVCLSKEAERTLLTWESVHKENFLLAQARDKRDSDSERLKRTSQKVDTALKQLGQIREYDRRLRGLEREVQHCSRVLTWMAEALSHSALLPPGGPPPPSPTGSKD
PDB Structures
Ligand Binding
Binding Site
172;422;449;822;825;859;862
Disease
Location
Isoform 1 is highly expressed in the testis with a moderate expression in the brain; spleen and thymus. Isoform 2 is only expressed in the brain and spleen.
DOI ID
10.1038/nature02426; 10.1016/j.bbrc.2009.11.142; 10.1046/j.1540-8167.2004.03477.x; 10.1161/01.hyp.0000237864.65019.a5; 10.1038/ncomms1871
RefSeq
NP_001129701.1 [Q9ESQ5-1];